Tumor Type

Canada
Germany
(partner)
Brain Cancer - Pediatric Medulloblastoma
Funding Organizations
Research Organizations
Research Activities
Publication Policy

1:   ICGC Goals, Structure, Policies and Guidelines Section E.3 - Publication Policy HTML 
2:   Template Letters to Facilitate Communications HTML 
to ensure appropriate dialogue between data users and generators and for authors to contact ICGC members and editors
Clinic & Pathology

Canada: McGill University
McMaster University
University of Toronto
Czech Republic: Masaryk University
France: University of Lyon
Germany: Cnopf’sche Kinderklinik
German Cancer Research Center (DKFZ)
Hungary: Semmelweis University
University of Debrecen
Italy: Catholic University Medical School
University of Naples
Netherlands: Erasmus University Rotterdam
Poland: The Children's Memorial Health Institute
Portugal: University of Lisbon
South Korea: Korea Chonnam National University
Seoul National University
University of Ulsan
United Kingdom: Newcastle University
United States: Case Western Reserve University
Johns Hopkins University
University of California, Los Angeles
University of California, San Francisco
University of Cincinnati
Virginia Commonwealth University
Washington University School of Medicine
Sequencing & Analysis

Canada: BC Cancer Agency - Michael Smith Genome Sciences Centre
Hospital for Sick Children (SickKids)
McGill University Health Centre
University of Calgary
University of Toronto
Complementary Studies

Canada: Hospital for Sick Children (SickKids)
University of British Columbia
Germany: German Cancer Research Center (DKFZ)
United Kingdom: Newcastle University
United States: Harvard Medical School
Data Storage, Analysis & Management

Canada: BC Cancer Agency - Michael Smith Genome Sciences Centre
Project Summary


Cancer is the leading cause of non-accidental death in children, and brain tumors (medulloblastoma) are the leading cause of pediatric cancer deaths in Canada. Those children who do manage to survive usually have a severely impaired quality of life due to the aggressive treatment for the disease. Strategies are needed to improve the quality of life for families of children with brain tumors, to increase survival rates, and to minimize the impact on health care systems.
Preliminary data suggests that some children with very good prognosis medulloblastoma are being over-treated with current regimens and could be spared complications by reducing the amount or type of treatment they receive. On the other hand, some children with very poor prognosis medulloblastoma die despite going through painful therapies that may in fact be futile. Reducing therapy in this group of patients could increase quality of life without changing their prognosis.
In this project, genomic analyses of pediatric medulloblastoma samples, obtained through the international medulloblastoma consortium, will be performed. RNA and miRNA expression profiles of 1000 samples, representing all four subgroups (Wnt, Shh, Group C, and D), will be studied to identify novel subtypes within each subgroup. The resulting subtype-specific expression profiles will support the development of reliable and robust biomarkers to more accurately and reliably classify medulloblastomas for treatment in clinical trials. For that purpose, two assays will be developed: an antibody-based immunohistochemical assay and an orthogonal nucleic acid-based hybridization assay.
Additional genomic DNA analysis of the 300 high risk subgroup cases will support the discovery of subgroup specific somatic mutations in order to inform current clinical trials of targeted therapies, and to identify genes and pathways already targeted in other diseases. Such therapies could be rapidly transitioned to Phase II trials in medulloblastoma. Furthermore, the discovery of somatic mutations could be used for developing as well as validating specific biomarkers.
The project team will also try to identify risk factors that predispose children to this type of cancer. Subgroups of children with medulloblastoma who have poor quality of life will be prioritized, and the team will work with families to quantify the additional risks they are willing to assume in reducing therapy to improve quality of life. The results of these experiments can very quickly inform global childhood clinical trials consortia to initiate trials of therapy- sparing treatment of medulloblastoma. It is anticipated that these studies will transform the way that children with medulloblastoma are treated and will have an immediate and lasting positive impact on both the survival and quality of life of children with this disease.

Principal Investigators

Michael D. Taylor, MD, PhD, FRCS
Marco A. Marra, PhD, FRSC
David Malkin, MD, FRCP

Lead Jurisdiction