Tumor Type

United States
Head And Neck Cancer - Squamous cell carcinoma of oral cavity / oropharynx / sinonasal cavity / hypopharynx / larynx
Project Profile
Funding Organizations
Research Organizations
Research Activities
Publication Policy

1:   ICGC Goals, Structure, Policies and Guidelines Section E.3 - Publication Policy HTML 
2:   Template Letters to Facilitate Communications HTML 
to ensure appropriate dialogue between data users and generators and for authors to contact ICGC members and editors
Clinic & Pathology

United States: Broad Institute
University of Pittsburgh Department of Pharmacology and Chemical Biology

Jennifer Grandis at the University of Pittsburgh is contributing efforts in patient recruitment, clinical sample collection, pathology review and data analysis.

The Broad Institute is contributing efforts in secondary pathology review, clinical data management and analyte quality control.

Sequencing & Analysis

United States: Broad Institute
Dana-Farber Cancer Institute
University of Pittsburgh Department of Pharmacology and Chemical Biology
Complementary Studies

Data Storage, Analysis & Management

United States: National Center for Biotechnology Information

Sequencing, SNP, copy number, and somatic variant calls will be stored at the NCBI short read archive as well as dbGAP for data sharing and distribution purposes.

The dbGAP accession number for this sequencing project is phs000370.v1.p1.

Project Summary

Head and Neck Squamous Cell Carcinoma (HNSCC) is a common frequently lethal malignancy that is among the most common causes of cancer death in Mexico. Little is known about the molecular basis of HNSCC, and to date there are no molecularly targeted treatments available. To gain insight into the disease and discover potential targets for therapies, we have initiated a comprehensive HNSCC cancer genome sequencing effort, and have completed the characterization, sequencing and analysis of 92 patients.

dbGaP Study

Slim Initiative for Genomic Medicine:

This work is conducted as part of the Slim Initiative for Genomic Medicine (SIGMA), a joint U.S.-Mexico project funded by the Carlos Slim Health Institute. The SIGMA cancer project aims to understand the genomic basis of cancer in worldwide populations by extensive analysis of at least 560 cancer pairs across at least 7 different cancers to obtain an initial molecular taxonomy of the mutations present in these cancer types.

Principal Investigators

Todd Golub
Levi Garraway
Jennifer Grandis

Lead Jurisdiction