Tumor Type

Blood Cancer - T-cell and NK-cell lymphoma
Project Profile
Funding Organizations
Research Organizations
Research Activities
Publication Policy

1:   ICGC Goals, Structure, Policies and Guidelines Section E.3 - Publication Policy HTML 
2:   Template Letters to Facilitate Communications HTML 
to ensure appropriate dialogue between data users and generators and for authors to contact ICGC members and editors
Clinic & Pathology

Singapore: Singapore General Hospital
National University Hospital
National University Cancer Institute, Singapore
China: Sun Yat-sen University Cancer Center
Singapore: National Cancer Center of Singapore

Details to follow

Sequencing & Analysis

Singapore: Duke-NUS Graduate Medical School (Singapore)
National Cancer Center of Singapore
Genome Institute of Singapore

Details to follow

Complementary Studies

Singapore: National Cancer Center of Singapore

Details to follow

Data Storage, Analysis & Management

Singapore: Duke-NUS Graduate Medical School (Singapore)
Genome Institute of Singapore

Details to follow

Project Summary

Lymphomas are malignancies originating from the lymphatic system and there is a worldwide significant increase in incidences of this cancer. Lymphomas can be further classified into 2 categories namely Hodgkin’s (HL), and Non-Hodgkin’s lymphoma (NHL). The latter can be divided further into B, T and NK cell NHL. Peripheral T-cell lymphoma (PTCL) and Natural Killer/ T-cell lymphoma (NKTL) arise from mature T lymphocytes and NK cells. The more common subtypes include NKTL, PTCL not-otherwise-specified (PTCL-NOS), systemic anaplastic large cell lymphoma (ALCL), follicular PTCL (F-PTCL), angioimmunoblastic T-cell lymphoma (AITL) and enteropathy-associated T-cell lymphoma (EATL). Both PTCL and NKTL occur at significantly higher frequencies in Asia compared to the West. Genetic and environmental factors, in particular EBV infections, have been implicated. NKTL, for instance, is almost always associated with Epstein Barr Virus (EBV) infection and several subsets of PTCL like AITL are also frequently associated with EBV infection. To make progress in diagnosis, prognostication and therapeutic intervention in PTCL and NKTL, a better understanding of the pathogenesis and biology of these tumors is urgently needed.

As contributing member to ICGC project, the whole genome analyses will be performed in T-cell and NK-cell lymphoma samples from various countries. Analyses will include whole genome sequencing, structural and copy number variation determination and pathogen integration. Comprehensive profiling and comparison among patients from various countries with different etiopathogenesis will facilitate the elucidation of key pathways and underlying molecular mechanisms driving these cancers, opening up novel therapeutic strategies in the future.

Principal Investigators

• Choon Kiat Ong
• Soon Thye Lim
• Patrick Tan
• Steven Rozen

Lead Jurisdiction