Tumor Type

United States
Pediatric Brain Tumor - Multiple subtypes
cbttc.org  HTML pnoc.us  HTML cavatica.org  HTML
Project Profile
Funding Organizations
Research Organizations
Research Activities
Publication Policy

1:   ICGC Goals, Structure, Policies and Guidelines Section E.3 - Publication Policy HTML 
2:   Template Letters to Facilitate Communications HTML 
to ensure appropriate dialogue between data users and generators and for authors to contact ICGC members and editors
Clinic & Pathology

United States: Children's Hospital of Philadelphia
Ann & Robert H. Lurie Children's Hospital of Chicago
Seattle Children’s Hospital
Joseph M. Sanzari Children’s Hospital at Hackensack University Medical Center
Children's Hospital of Orange County
University of California Santa Cruz – Treehouse Childhood Cancer Initiative
China: Beijing Tiantan Hospital Neurosurgery Center
Genebank (Beijing Genomics Institute)
United States: Children’s National Health System
Children’s Hospital of Pittsburgh of UPMC
Italy: Meyer Children’s Hospital
United States: The Bristol-Myers Squibb Children's Hospital at Robert Wood Johnson University Hospital
Stanford University/Lucile Packard Children’s Hospital
University of California San Francisco Benioff Children’s Hospital
Weill Cornell Medicine Pediatric Brain and Spine Center
Dana-Farber Cancer Institute
St. Louis Children’s Hospital
Nationwide Children's Hospital
St. Jude Children’s Research Hospital
Doernbecher Children's Hospital - Oregon Health & Science University
University of Utah Health
University of California San Francisco Benioff Children’s Hospital Oakland
Children's Hospital Los Angeles
Rady Children's Hospital - San Diego

Children’s Brain Tumor Tissue Consortium (CBTTC)
The mission of the CBTTC is to collect high-quality brain tumor and associated biofluid specimens with correlative clinical data, de-identify the materials, facilitate the generation and integration of data from biospecimens, develop cell lines and transplantable tumor models from submitted specimens, and empower shared discovery of with the world-wide scientific and medical communities.

The Pacific Pediatric Neuro-Oncology Consortium (PNOC)
PNOC was formed to provide children with brain tumors access to innovative, individually-defined treatments, pursuing clinical strategies that are based on the molecular and genetic make-up of each tumor. Clinical trials employ therapies aimed at interfering with specific cellular pathways or mutations after confirming that a patient’s tumor has those characteristics, sparing patients therapy that is not optimized for their tumor type.

Sequencing & Analysis

United States: Children's Hospital of Philadelphia
Beijing Genomics Institute
Children's Hospital of Orange County
Translational Genomics Research Institute

Details to follow

Complementary Studies

United States: The Children’s Brain Tumor Tissue Consortium - Scientific Projects
The Pacific Pediatric Neuro-Oncology Consortium - Clinical Trials

The CBTTC strives to provide high-quality biospecimens with annotated clinical and genomic data to facilitate and advance childhood brain tumor research. More than 16 projects to date have been supported across more than 1600 patients. PNOC is currently conducting 5 clinical trials across 15 institutions.

Data Storage, Analysis & Management

United States: CAVATICA

The CAVATICA commons is supported by Cavatica data analysis and sharing platforms designed to accelerate discovery in a scalable, cloud-based compute environment where data, results, and workflows are shared among the world's research community.

Project Summary

The CBTTC and PNOC collectively represent more than 20 pediatric hospitals committed to propelling precision medicine forward through the collaborative generation and rapid distribution of large-scale research and clinical trial genomic data with the aim of breaking down barriers that inhibit research and driving discoveries that will lead to faster treatments and cures for pediatric brain tumors.

Brain, Spinal Cord, and other Pediatric Cancers:
• Low-grade glioma/astrocytoma (WHO grade I/II)
• Ependymoma
• High-grade glioma/astrocytoma (WHO grade III/IV)
• Medulloblastoma
• Ganglioglioma
• Supratentorial or Spinal Cord PNET
• Craniopharyngioma
• Atypical Teratoid Rhabdoid Tumor (ATRT)
• Meningioma
• Brainstem glioma-Diffuse intrinsic pontine glioma
• Dysembryoplastic neuroepithelial tumor (DNET)
• Neurofibroma/Plexiform
• Schwannoma
• Metastatic secondary tumors
• Choroid plexus papilloma
• Dysplasia/Gliosis2
• Germinoma
• Choroid plexus carcinoma
• Oligodendroglioma
• Adenoma
• Teratoma
• Non-germinomatous germ cell tumor
• Pineoblastoma
• Malignant peripheral nerve sheath tumor (MPNST)
• Chordoma
• Neurocytoma
• Langerhans Cell histiocytosis
• Gliomatosis Cerebri
• Primary CNS lymphoma

Funding Organizations:
John McNicholas Pediatric Brain Tumor Foundation
The Ross K MacNeill Foundation
At Least Kids Foundation
• Brendan Bovard Fund for Brain Tumor Research
Eaise Family Foundation, Inc.
Grayson Saves Foundation
Naya Foundation
• Perricelli Hope Foundation
The Christopher Court Foundation
Al Musella Foundation
Defeat DIPG
Lilabean Foundation
Matthew Larson Foundation
On Course Fore a Cure
Smashing Walnuts
The Cure Starts Now Cancer Foundation
Pediatric Brain Tumor Research Guild
Alex Munoz Foundation
Brandles Joy of Hope
Bryce Hansen Bridge of Hope Fund
Chester County Community Foundation
Children's Brain Tumor Foundation
Dragon Master Foundation
Hanna Duffy Foundation
International Licensing and Merchandiser’s Association
Joseph T. Lentz Pediatric Brain Cancer Research Fund
Kayla’s Hope for Kids Fund
Kyle Daniel Kerpan Foundation
Lauren’s First and Goal
Miriam’s Kids Research Foundation
PLGA Foundation
Stanley’s Dream
Swifty Foundation
The CJR Memorial Foundation
The Kortney Rose Foundation
• The Matthew Renk Foundation
Thea’s Star of Hope
Vs Cancer Foundation
Why Not Me? Foundation
Wylie’s Day Foundation
PNOC Foundation
Ivy Foundation

Principal Investigators

Adam C. Resnick Ph.D.
Director of the Center for Data Driven Discovery in Biomedicine (D3b)
Director of Children's Brain Tumor Tissue Consortium in Neurosurgery (CBTTC)
Scientific Chair, Children's Brain Tumor Tissue Consortium (CBTTC)
Scientific Chair, Pediatric Neuro-Oncology Consortium (PNOC)
The Children's Hospital of Philadelphia

Sabine Mueller, MD, PhD
Director, Pediatric Brain Tumor Center, UCSF
Co-project leader of the Pacific Pediatric Neuro-Oncology Consortium (PNOC)

Lead Jurisdiction