Tumor Type

Melanoma -
Project Profile
Funding Organizations
Research Organizations
Research Activities
Publication Policy

1:   ICGC Goals, Structure, Policies and Guidelines Section E.3 - Publication Policy HTML 
2:   Template Letters to Facilitate Communications HTML 
to ensure appropriate dialogue between data users and generators and for authors to contact ICGC members and editors
Clinic & Pathology

Brazil: Centro de Estudos em Biodireito, Pontifical Catholic University of Minas Gerais
Molecular Oncology Research Center - Barretos Cancer Hospital
Canada: Department of Pathology and Molecular Medicine - Queen's University

The samples were retrospectively collected from Barretos Cancer Hospital institutional Tissue Biobank. All collected samples had a previously signed informed consent by patients or legal representatives, which explained and asked permission to collect tissue for research proposes. All procedures executed in the tissue biobank have implemented standard operational procedures for quality assurance, based upon international standards, aiming to standardize the collection, freezing, storage and tracking of samples. All cases stored on the tissue biobank are provenient from patients that had their oncological treatments at Barretos Cancer Hospital and have FFPE specimen at the Pathology Department and the pathology report is archived at the Institution’s electronic health record system. Updated and accurate follow-up information data from patients’ samples is available for all cases.

Sequencing & Analysis

The CEBIO was installed in 2008 aiming to undertake genomic studies of microorganisms, large bodies and environments, in order to generate knowledge to assist health, industry and academia. The CEBIO has the highest capacity to generate genomic data in Latin America. Whole-genome sequencing of 100 paired tumor/normal cases will be performed using the SOLiD V4 platform.

Complementary Studies

Details to follow

Data Storage, Analysis & Management

Details to follow

Project Summary

The Brazilian project aims to map the genomics of melanoma, which is the most aggressive form of skin cancer, with an increasing incidence in the world and particularly in Brazil. Melanoma is a major medical challenge due to their great genetic diversity, which determine the treatment of the patients.
The Brazilian initiative results from a partnership between the HCB, which has one of the largest tumor banks in Latin America, as well as a Molecular Oncology Research Center that is equipped with modern technologies to study the biology of the cancer, and CEBIO, which has the greater ability to generate genomic data from Latin America, whose scope of work involves genomic studies of micro-organisms, large bodies and environment, in order to generate knowledge to assist health, industry and academia. This initiative also includes the participation of the Centre for Studies in Biolaw from PUC-Minas, and with the inclusion of Queens University, Kingston, Canada, where the findings of the Brazilian population with melanoma will be compared with those of the Canadian population.

Principal Investigators

• André Lopes Carvalho
• Guilherme Oliveira
• Rui Manuel Reis
• Vinicius de Lima Vazquez

Lead Jurisdiction