ICGC Goals, Structure, Policies & Guidelines April 2008

ICGC Goals, Structure, Policies & Guidelines April 2008: PDF

D. Structure of the Consortium

Section D – Structure of the Consortium PDF


E.1  Informed Consent, Access and Ethical Oversight

Section E.1 – Informed Consent, Access and Ethical Oversight PDF


E.3  Publication Policy

Section E.3 – Publication Policy PDF


E.6 Quality Standards of Samples

Section E.6 – Quality Standards of Samples PDF


E.7 Study Design and Statistical Issues

Section E.7 – Study Design and Statistical Issues PDF


Updates to Goals, Structure, Policies & Guidelines

Coordination

April 2008 March 2010, Current

An International Scientific Steering Committee (ISSC) will be constituted with the principal investigators of cancer genome projects in the ICGC, the Data Coordination Center, expert pathologists, oncologists and ethicists, and representatives of funding agencies. This group will interact frequently, through phone conferences, e-mail and regular meetings, to:

  • act as a science coordinating body;
  • evaluate progress;
  • address arising issues of a scientific nature, including those related to samples,
    consent, ethics, quality standards, evolving technologies;
  • exchange protocols, standard operating procedures;
  • establish temporary or permanent subcommittees that would be assigned focused
    tasks;
  • establish QC standards.

A Data Coordination Center (DCC) will manage data flow from projects and centers to the central ICGC database, public repositories, quality assessment, curation and data releases (see details in section E.9 Data Management). The DCC will provide regular progress reports to the EXEC and ISSC.

Quality Assessment Centers
Quality assessment of the samples used in cancer genome projects is critical to the success of the project. To that end, the Consortium may consider establishing quality assessment centers. The issue of ‘round robin’ style versus 3rd party quality assessment will require further discussion, as well as mechanisms for funding such activities.

Coordination Support
Staffing will be committed to help manage the operations of the ICGC committees.